Moliere holds each of us accountable when he asserted that “It is not only for what we do that we are held responsible, but also for what we do not do.” Responsible Engineering and Living 2022 (REAL2022) strives to inspire every individual to practice and foster responsible engineering and living. REAL2022 aims to bring all stakeholders, enthusiasts, and experts from academia, industry, policy arenas, and the general public together to discuss challenges, sharpen existing solutions, and formulate novel means to advance responsible engineering and living. This symposium will disseminate recent progress and promote collaborations to maximize opportunities for innovative solutions. Topics of interest include resource and energy conservation, waste reduction, nature-friendly engineering and architecture, and sustainable vibrant living.